How to design in situ studies: an evaluation of experimental protocols
성영혜, 김해영, 손호현, 장주혜,
소속 상세정보
성영혜 ( Sung Young-Hye ) - Seoul National University School of Dentistry Department of Conservative Dentistry
김해영 ( Kim Hae-Young ) - Korea University Graduate School Department of Public Health Sciences
손호현 ( Son Ho-Hyun ) - Seoul National University School of Dentistry Department of Conservative Dentistry
장주혜 ( Chang Ju-Hea ) - Seoul National University Dental Hospital Clinic for Persons with Disabilities
KMID : 1034420140390030164
Abstract
Objectives: Designing in situ models for caries research is a demanding procedure, as both clinical and laboratory parameters need to be incorporated in a single study. This study aimed to construct an informative guideline for planning in situ models relevant to preexisting caries studies.
Materials and Methods: An electronic literature search of the PubMed database was performed. A total 191 of full articles written in English were included and data were extracted from materials and methods. Multiple variables were analyzed in relation to the publication types, participant characteristics, specimen and appliance factors, and other conditions. Frequencies and percentages were displayed to summarize the data and the Pearson's chi-square test was used to assess a statistical significance (p < 0.05).
Results: There were many parameters commonly included in the majority of in situ models such as inclusion criteria, sample sizes, sample allocation methods, tooth types, intraoral appliance types, sterilization methods, study periods, outcome measures, experimental interventions, etc. Interrelationships existed between the main research topics and some parameters (outcome measures and sample allocation methods) among the evaluated articles.
Conclusions: It will be possible to establish standardized in situ protocols according to the research topics. Furthermore, data collaboration from comparable studies would be enhanced by homogeneous study designs.
키워드
In situ; Caries; Demineralization; Remineralization; Erosion; Materials and methods
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